CBD Cream

Whether it’s acne, psoriasis, or eczema, everyone has some trouble with their skin from time to time. There’s no reason to be ashamed of ‘bad skin’; but there’s no reason to live with it, either! Multiple studies have implied that CBD balm and cream has the potential to affect your skin, along with symptoms of some conditions. If you want to use CBD for your skin, take a look at these lovely ranges of CBD creams and balms! Check out other types of products - CBD Oil | CBD Vape | CBD Capsules & Categories - Pain | Sleep | Anxiety
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A Guide To CBD Creams

 alphagreen A Guide To CBD Creams

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A short, concentrated article on how CBD creams can provide localised, pain-relieving and nourishing benefits, when topically applied onto the skin. In particular, we focus on how CBD creams can suit a variety of inflammatory skin disorders and provide antioxidative benefits for skin health.


Whatever climate you’re in, your skin still deserves to be nourished, moisturised and hydrated; after all, your skin is your biggest organ.

And what better way to look after your skin, than with CBD-infused creams? You might be wondering what CBD can do for your skin; you’ve come to the right place. Because, at Alphagreen, we love all things CBD. And, since CBD was discovered, its therapeutic potential extends way beyond the physiological- and into the physical.

All in all, CBD’s potential to provide some serious skincare benefits, from helping to keep free radicals away to clearing up acne and inflammation, has become a game-changer for skincare.

The Benefit of CBD Creams

So, when it comes to CBD creams, there’s a lot of guarantees- but the two main benefits of CBD-infused creams circulate around cannabidiol as a powerful antioxidant and a powerful anti-inflammatory.

Let’s explore how CBD can be used to heal a wealth of skin disorders, all while maintaining the health and glow of the skin.

How Do CBD Creams Work?

 alphagreen A Guide To CBD Creams

Perfect for any skin type, packed with antioxidants and able to be absorbed into the pores of the skin, CBD creams can suit a wide range of our skincare needs.

When we massage CBD-infused cream into the skin, a number of things happen. First and foremost, we rub the cream into our skin- stimulating our sensitive cutaneous nerve endings, evoking sensations of ‘pleasure’ and encouraging blood circulation to occur. This allows toxins to be carried away, while ensuring that the skin absorbs any product we apply much better.

Next, CBD in the cream, once absorbed through the pores, begins to act in the therapeutic manner. Not only does CBD interact with the endocannabinoid system to reduce the symptoms of various skin diseases (psoriasis and dermatitis being a few which come to mind), prevent inflammation and dull symptoms of pain, CBD also helps to fight acne, reduce irritation and is is packed with antioxidants to keep the skin healthy and strong.

CBD As An Antioxidant

CBD is a powerful antioxidant- making it a valuable ingredient for maintaining healthy, strong skin. Antioxidants are important for a host of reasons- and should be present in everyone’s skincare routines.

Antioxidants prevent the build up of harmful molecules known as free radicals. Free radicals have one defining characteristic: they have one, or more, unpaired electron, making them highly likely to steal electrons from stable cells and render those skin cells unstable. This can cause a ‘chain reaction’ of free radicals in the system. Our skin can’t really avoid free radicals. They tend to absorb into the skin through a range of different exposures, some of which include exposure to:

  • Cleaning chemicals
  • Pollutants
  • Vehicle engines
  • UV rays
  • Radiation

Since free radicals are highly reactive and tend to be unstable, antioxidants are responsible for neutralising them- thus rendering free radicals less reactive and dangerous. Without enough antioxidants to neutralise these free radicals, you can end up having oxidative stress occur. This happens when free radicals are left to ‘chain react’ with as many stable molecules as they want- rendering those stable molecules unstable, and potentially destroying cells, tissues and even organs. In the skin, this can lead to serious dangers.

Too much free radical exposure and not enough antioxidants can have serious consequences for your skin. Often, without antioxidants, free radicals can end up damaging the skin cells to such a degree, it can lead to the development of harmful skin diseases or skin cancer.

So what allows CBD topicals to provide such great antioxidative properties? According to studies, CBD prevents the formation of superoxide radicals, reducing levels of Nitrous Oxide in the system and reducing the levels of reactive oxygen species (also known as ROS molecules- similar to free radicals) which, when left unchecked, can form highly reactive hydroxyl free radicals.

 alphagreen A Guide To CBD Creams

In some studies, researchers also found that CBD increased the levels of the antioxidant/enzyme, superoxide dismutase (SOD), responsible for metabolising, and therefore, eliminating superoxide radicals. CBD does this by helping to activate a specific transcription factor which increases the mRNA level of SOD, alongside other beneficial antioxidants/enzymes- in particular, copper, zinc and manganese.

CBD As An Anti-Inflammatory

CBD can also provide anti-inflammatory benefits, making it great in treating the symptoms of skin flare-ups- from psoriasis to acne.

According to scientific journals, the process of skin inflammation usually involves a number of factors- typically, these include cells or molecules such as cytokines, platelets, macrophages or keratinocytes getting in the way of balance and homeostasis in the skin. Skin-homeostasis means a number of things- it can involve keeping a balanced immune response, as well as maintaining cell differentiation and replication. Usually this allows the skin to be clear, healthy and hydrated.

Inflammation upsets skin-homeostasis by stimulating an imbalance of T cells- since inflammation is an immune response, it’s purpose is pure: to prevent harmful, foregin substances from getting into the body by ensuring more immune cells are present at the site of the infection. What actually causes inflammation to occur are little molecules known as cytokines, which activate the T cells into action. However, this almost always triggers a response on the skin’s surface- which often manifests in discomfort, itching, redness, scaliness or bumps/cysts.

Sometimes, the body isn’t able to regulate its own immune response, leading to skin disorders which are disproportionately triggered (by a stimulus which usually doesn’t lead to such a strong inflammatory response) or by no trigger at all. These skin disorders often become flare ups or chronic, some of which include: psoriasis, acne, allergic contact dermatitis, dermatomyositis, scleroderma and more.

CBD can be valuable as a topical anti inflammatory, due to it raising levels of anandamide and 2-AG in the system- since these endocannabinoids are highly involved in the therapeutic response, from easing pain to promoting relaxation and wellbeing, they can prove valuable. Here’s some examples of CBD helping to prevent the inflammatory symptoms of some inflammatory skin disorders.


Psoriasis is an autoimmune inflammation response- the body mistakes the epidermal proliferation (the creation of skin cells) with something harmful, which stimulates proinflammatory cytokines to be released. T-cells, keratinocytes, immune cells and dendrocytes all work to promote this inflammatory response.

CBD comes into the picture here. Specifically helpful for psoriasis, CBD can prevent the build up of keratinocytes- which are responsible, in a large part, for the visible reaction we tend to see in those who have been diagnosed. CBD is also essential in switching up the T cells which are released by the body. Studies show that, with CBD in the system, the proinflammatory T cells, Th1 convert to anti-inflammatory Th2 cells, restoring the Th1/Th2 balance and allowing the visible signs of inflammation to ease.


 alphagreen A Guide To CBD Creams

Often triggered by seborrhea, hormonal imbalance or environmental factors, acne is an inflammatory response which can be soothed by CBD.

Since, CBD triggers higher levels of anandamide and 2-AG, these endocannabinoids can activate TRPV1, TRPV2 and TRPV3 receptors on the skin’s surface, as well as increasing the levels of the hormone, adenosine- a combination of these two factors helps to prevent the skin from overproducing sebum and sebocytes.

CBD can also prevent proinflammatory cytokines from releasing, especially in those who suffer from recurrent acne.

Allergic Contact Dermatitis

ACD is a hypersensitive skin reaction, where T cells and cytokines are released in response to an allergen touching the skin. This could be anything, from a specific ingredient in a skincare product to perfume or dust particles.

A CBD cream can be a great way to combat allergic contact dermatitis- not only does CBD limit the number of Th1 T cells from producing, it inhibits the build-up of keratinocyte cells on the surface of the skin. CBD does this by inhibiting the protein (MCP-2) which is a proinflammatory molecule, known as a chemokine.

 alphagreen A Guide To CBD Creams

Anandamide and 2-AG are also capable of binding to CB1 receptors on the surface of the skin- directly influenced by the presence of CBD in the system. According to a wealth of skincare studies, CB1 agonists, such as these endocannabinoids, are capable of preventing inflammation from occurring, by infiltrating a number of important pathways. For example, a pathway that does get blocked is the creation of certain chemokines. This stops the inflammatory-causing molecules from being produced, as their synthesis is interrupted.

Something which CB1 agonists stimulate, in the skin, is the activation of PPARs- these are the receptors responsible for aiding in various skin disorders by modulating cell proliferation and differentiation. This can be a great win for CBD since NSAIDs are said to work by, similarly, activating PPARs to fix a variety of skin conditions.


Dermatomyositis symptoms include skin rash, redness, and the regeneration of muscle tissue- it can be quite a serious condition which can lead to stiff joints and muscle erosion over time. Since the condition is autoimmune, the inflammation is said to be driven by the activation of lymphocytes (white blood cells, and immune system function) and dendritic cells (which are responsible for presenting antigens- which are a crucial part of antibody production within the immune system function).

In a person with dermatomyositis, lymphocytes and dendritic cells overproduce inflammation-causing molecules, some including proteins called interferons. Interferons are responsible for cell growth and inflammation. In those who have dermatomyositis, interferons (alongside other inflammatory molecules) aren’t responding to any foreign threat, In many instances, this skin disorder can lead to disease of the blood vessels.

CBD can be useful for this, since it indirectly stimulates CB2 receptors- which can inhibit the production of cytokines and prevent interferons from being produced. The cannabinoid ajulemic acid (present in many full and broad spectrum CBD topicals) has also been shown to be promising in helping to combat dermatomyositis. According to studies, ajulemic acid has an incredibly high affinity for CB2 receptors, naturally reduces inflammation and is so successful in helping to combat symptoms of this skin disorder, that it’s currently undergoing phase 2 trials.

A full, or broad spectrum, CBD cream will allow for the synergistical ‘entourage effect’ to occur at greater levels. This means that, not only will the CBD topical contain ajulemic acid, all the cannabinoids within the cream can work together to produce a more powerful healing effect.


CBD creams, and other such topicals, have undergone trials and tests- only to come out strong.

Drawing on CBD’s manipulation of the endocannabinoid system, the ‘entourage effect’ and natural antioxidative properties, CBD is clearly a powerful contender for healthy, nourished skin.


What’s The Difference Between Oral and Topical CBD?

While the skin is our largest organ, when we take CBD orally, it goes through our digestive tract and gets metabolised by the liver. The effects are, therefore, usually felt a few hours after ingesting- and even then, the CBD might not have time to fix up any skin issues. The body is big and CBD’s effects, when taken orally, tend to have a more ‘umbrella’ approach- meaning, like an umbrella, the effects of CBD encompass different parts of the body, instead of having a specific effect.

How Do Topical CBD Creams Work?

When we apply a CBD topical, such as a cream, to the skin, the CBD has a higher bioavailability than if you take it orally (since the CBD doesn’t have to pass through the digestive system). Topical CBD is more localised and, therefore, more concentrated. It’s often best used to treat concentrated physical symptoms, since the CBD never enters the bloodstream to reach other organs/body parts.

How Do CBD Creams Enter the Skin?

Topicals, like CBD creams, absorb into our pores. The CBD never enters the bloodstream- so it doesn’t get carried away from the localised area. Instead, the CBD indirectly activates CB1 and CB2 receptors on the surface of the skin- promoting healing, protection and other benefits.

Are There Side-Effects To CBD Creams?

With topical CBD creams, there are very few side-effects to report; unless you’re allergic to any of the ingredients or scents within the topical. Be sure to carefully check the back of any product, the ingredients and perfumes listed (if any) and the 'how to apply’ section, which should be on the back of every skincare product, by law.

Can CBD Creams Curb Anxiety?

CBD creams can help with anxiety in a number of ways- with relaxing, uplifting and calming scents. Likewise, rubbing or massaging the skin can stimulate the cutaneous nerves and promote relaxation, tension-relief and pleasure.

However, for a more ‘hands-on’ approach to anxiety relief, we recommend taking CBD orally. Studies show that a few drops of CBD oil can promote a stronger sense of relaxation, anxiety-relief and reduce fear.

Can CBD Creams Curb Anxiety?

CBD creams can help with anxiety in a number of ways- with relaxing, uplifting and calming scents. Likewise, rubbing or massaging the skin can stimulate the cutaneous nerves and promote relaxation, tension-relief and pleasure.

However, for a more ‘hands-on’ approach to anxiety relief, we recommend taking CBD orally. Studies show that a few drops of CBD oil can promote a stronger sense of relaxation, anxiety-relief and reduce fear.

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